PRO2

Clinical intent

The PRO2 is a Patient-reported outcome derived from the Crohn's Disease Activity Index (CDAI) and determines the current severity of Crohn’s disease[1,2].

Calculation of the PRO2 was implemented as agreed upon by AZ Delta, AZ Maria Middelares and Imelda. Specifications can be found in this file

Calculation

SF & AP Subscore

A subscore for Stool Frequency (SF) and Abdominal Pain (AP) is calculated by summing the weighted scores for these categories.

Total score

The total score is the sum of all weighted scores.

References

[1] Jairath V, Khanna R, Zou GY, Stitt L, Mosli M, Vandervoort MK, D'Haens G, Sandborn WJ, Feagan BG, Levesque BG. Development of interim patient-reported outcome measures for the assessment of ulcerative colitis disease activity in clinical trials. Aliment Pharmacol Ther. 2015 Nov;42(10):1200-10. doi: 10.1111/apt.13408. Epub 2015 Sep 21. PMID: 26388424.
[2] Marin J. de Jong et al. Patient-Reported Outcome Measures for Use in Clinical Trials and Clinical Practice in Inflammatory Bowel Diseases: A Systematic Review. Clinical Gastroenterology and Hepatology 2018;16:648–663.
[3] Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439-44.